How reproducible are real-world research utilizing medical apply knowledge? – Healthcare Economist

That’s the query posed by a paper by Wang, Sreedhara and Schneeweiss (2022). The authors replicate the findings from n=250 real-world knowledge research. The research had been replicated utilizing 3 datasets: (i) Optum Clinformatics claims knowledge, (ii) IBM MarketScan Analysis Database claims knowledge, Medicare fee-for-service claims knowledge, and (iii) CPRD digital well being data. Key paper findings are beneath:

Authentic and replica impact sizes had been positively correlated (Pearson’s correlation = 0.85), a robust relationship with some room for enchancment. The median and interquartile vary for the relative magnitude of impact (e.g., hazard ratiooriginal/ hazard ratioreproduction) is 1.0 [0.9, 1.1], vary [0.3, 2.1]. Whereas the vast majority of outcomes are carefully reproduced, a subset usually are not. The latter could be defined by incomplete reporting and up to date knowledge. Better methodological transparency aligned with new steering could additional enhance reproducibility and validity evaluation, thus facilitating evidence-based decision-making

This paper received the 2023 Award for Excellence in Well being Economics and Outcomes Analysis Methodology. You may learn the complete paper right here.